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Research Faculty

CMM maintains 130 plus faculty in 28 departments and institutes. We have close ties with the top ranked Johns Hopkins Hospital, creating an ideal environment for translational research with unprecedented access to physician-scientists, patients and clinical trials.

Among graduate programs at Johns Hopkins, CMM is unique in that faculty membership does not occur by the default process of appointment in any department or institute, but through application. The size of the faculty pool has remained nearly constant for optimum faculty: student interactions.
Faculty_Mentors_2015v2

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The CMM graduate program is an interdisciplinary program of study. As such, our faculty list reflects our diversity with a balance of basic science and clinical researchers. They are members of various departments such as Biological Chemistry, Medicine, Molecular Biology and Genetics, Neuroscience, Oncology, Pathology, Pediatrics, Pharmacology, Physiology, Psychiatry, and Urology. Below is a list of CMM faculty listed by general area of research.

Applications for new preceptors may be made at any time during the year but are reviewed annually by the Policy Committee, with appointments beginning in the Fall, at the start of the academic year. Potential mentors are evaluated for their “research fit” with the goals of the CMM program, excellence of research, track record in mentoring, and availability of funding, space and resources. Junior faculty without extensive track records may be mentored by senior program faculty.

The responsibilities of preceptors include:

1. host CMM students for rotations and thesis research
2. contribute to didactic lectures, journal clubs, or other core academic activities
3. participate in CMM retreat, admissions, qualifying examinations and other program events

Cancer

  • Mary Armanios, MD
    • Biology and genetics of telomere-mediated disease and age-related stem cell failure
  • Stephen B. Baylin, MD
    • Molecular determinants of human tumor progression
  • Zaver M. Bhujwalla, PhD
    • Molecular and functional imaging of cancer and theranostic imaging
  • Ivan Borrello, MD
    • Development of an autologous graft vs. tumor effect early post-transplant that can be maintained by tumor-specific vaccinations
  • Robert A. Casero, Jr., PhD
    • Molecular pharmacology, polyamine metabolism, antineoplastic drug development
  • James R. Eshleman, MD, PhD
    • Mutator phenotypes in colon cancer, novel therapeutics
  • Andrew P. Feinberg, MD, MPH
    • Epigenetics of cancer and common disease; methylation and chromatin mechanisms
  • Alan D. Friedman, MD
    • Myeloid leukemogenesis, transcriptional control of hematopoietic differentiation
  • Sandra B. Gabelli, PhD
    • Molecular mechanism of deregulation in cardiovascular, cancer and parasitic disease: structural and biochemical analysis
  • Edward Gabrielson, MD
    • Functional genomics and molecular genetics of breast and lung cancer
  • Carol Greider, PhD
    • Telomerase biochemistry and telomere length regulation
  • Andrew Holland, PhD
    • Chromosome segregation and centrosome duplication
  • Paula J. Hurley, PhD
    • The molecular basis of lethal prostate cancer
  • John T. Isaacs, PhD
    • Programmed (apoptotic) cell death as therapy for cancer
  • William B. Isaacs, PhD
    • Molecular biology and genetics of prostate cancer
  • Elizabeth Jaffee, MD
    • Development of vaccines for treatment of cancer
  • Yoon Young Jang, MD, PhD
    • Basic and clinical applications of hepatocytes derived from patient specific iPSCs.
  • Kenneth W. Kinzler, PhD
    • Cancer genetics and its application to the clinic
  • Marikki Laiho, MD, PhD
    • Cellular DNA damage response and p53
  • Mark Levis, MD
    • The development of molecularly targeted therapies for leukemia.
  • William Matsui, MD
    • Cancer stem cells; developmental biology; hematopoiesis: clinical translation and clinical trials
  • Alan Meeker, PhD
    • Our lab focuses on abnormal telomere biology as it relates to cancer initiation and tumor progression, as well as cancer biomarker discovery and validation
  • Stephen Meltzer, MD
    • Biomarkers and molecular genetics/genomics of malignant progression
  • William Nelson, MD, PhD
    • The molecular pathogenesis of prostate cancer
  • Drew M. Pardoll, MD, PhD
    • Regulation of antigen specific T cell responses and studies approaches to modify these responses for immunotherapy
  • Ben Ho Park, MD, PhD
    • Genetic approaches to breast cancer therapy
  • Peter L. Pedersen, PhD
    • • Cell energetics, its molecular and chemical basis and relationship to both Cancer and to the discovery of new therapies.
  • Kenneth Pienta, MD
    • Defining the tumor microenvironment of prostate cancer metastases and the development of new therapies for prostate cancer
  • Gregory J. Riggins, MD, PhD
    • The molecular basis of brain cancers and therapies directed against cancer-causing mutations and alterations.
  • Dipali Sharma, Ph.D.
    • Obesity-breast cancer molecular connection; Breast cancer prevention; endocrine therapy resistance
  • Donald Small, MD, PhD
    • Molecular biology of leukemia, molecularly targeted therapeutics, hematopoiesis, signal transduction
  • Saraswati Sukumar, PhD
    • Identify gene alterations in breast cancer for early detection and novel therapies
  • Phuoc T. Tran, MD, PhD
    • Mouse models of epithelial-mesenchymal transition (EMT) and oncogene addiction in lung, prostate and liver cancer; pre-clinical and clinical radiosensitizers
  • Victor Velculescu, MD, PhD
    • Cancer genomics
  • Bert Vogelstein, MD
    • Molecular genetics of human cancer and its translational implications
  • Michael Mingzhao Xing, MD, PhD
    • Cellular and molecular derangements in thyroid cancer and their clinical translation.
  • Srinivasan (Vasan) Yegnasubramanain
    • The Yegnasubramanian lab is focused on understanding the complex interplay between genetic and epigenetic alterations in carcinogenesis and disease progression, and on exploiting this understanding in developing novel biomarkers for diagnosis and risk stratification as well as in identifying targets for therapeutic intervention
  • Lei Zheng, MD, PhD
    • Understanding the mechanistic roles of tumor microenvironment in cancer development, metastasis and antitumor immune response

Cardiopulmonary and Vascular Biology

  • Mark E. Anderson, MD, PhD
    • The role of the multifunctional Ca2+/calmodulin dependent protein kinase II (CaMKII) as a central signal contributing to myocardial dysfunction and arrhythmias
  • Subroto Chatterjee, PhD
    • Signal transduction in atherosclerosis
  • Harry C. Dietz, MD
    • Molecular etiology of structural heart disease
  • Nick Flavahan, PhD
    • The overall goal of our laboratory is to investigate the cellular and molecular mechanisms and interactions that regulate blood vessel development, function and disease
  • William B. Guggino, PhD
    • Genetic disorders associated with defective fluid and electrolyte movement
  • David A. Kass, MD
    • Mechanisms underlying various forms of heart failure; developing novel treatments to combat it
  • Chulan Kwon, PhD
    • Understanding the mechanisms governing heart generation and regeneration
  • Brian O’Rourke, PhD
    • Mitochondrial ion channels, bioenergetics, and cardiac excitation-contraction coupling
  • Gordon F. Tomaselli, MD
    • Structure and function of ion channels

Cell Biology and Genetics of Human Diseases

  • Fred Bunz, MD, PhD
    • DNA damage signaling in cancer cells and stem cells
  • Shukti Chakravarti, PhD
    • Extracellular matrix functions in normal and diseased connective tissues
  • Linzhao Cheng, PhD
    • Human stem cell biology, engineering and transplantation
  • Thomas Clemens, PhD
    • Molecular mechanisms of insulin, IGF and GH on bond and skeletal muscle growth and function and regulation of angiogenesis in these organs*
  • Mark Donowitz, MD
    • Molecular biology and epithelial transport in signal transduction
  • Daniela Drummond-Barbosa, PhD
    • Control of ovarian stem cells and their differentiating progeny by diet, insulin, and other systemic signals; molecular mechanisms of meiotic maturation; Drosophila model system
  • Jennifer H. Elisseeff, Ph.D.
    • Regenerating tissue, mostly cartilage using stem cells
  • Peter Espenshade, PhD
    • Regulation of cholesterol homeostasis; therapeutics for heart disease
  • Janice Evans, PhD
    • Fundamental cell biological processes in the sperm and egg
  • Luis Andres Garza, MD, PhD
    • Using skin as a model system, the Garza lab studies regenerative medicine using cell culture, mouse and interventional human trials to learn more about basic biology and new cures for the clinic.
  • Kenneth W. Kinzler, PhD
    • Cancer genetics and its application to the clinic
  • Svetlana Lutsenko, PhD
    • Integrative approach to the analysis of liver and brain pathology, Wilson’s disease, human copper metabolism, biochemistry and cell biology of transmembrane ion transport
  • Susan Michaelis, PhD
    • We study the premature aging disease progeria and nuclear lamin A processing, as well as protein aggregation and degradation in yeast and mammalian cells.
  • Jeremy Nathans, MD, PhD
    • The physiology and pathophysiology of the mammalian visual system
  • Ben Ho Park, MD, PhD
    • Genetic approaches to breast cancer therapy
  • Peter L. Pedersen, PhD
    • • Cell energetics, its molecular and chemical basis and relationship to both Cancer and to the discovery of new therapies.
  • Joel Pomerantz, PhD
    • Mechanisms of Signal Transduction in Immunology and Cancer
  • Rajini Rao, PhD
    • Ion transporters in human health and disease
  • Roger H. Reeves, PhD
    • Disruption of development by gene dosage imbalance in Down syndrome
  • Ryan C. Riddle, PhD
    • Role of Wnt signaling in bone growth and the influence of the skeleton on whole-body metabolism
  • Lewis H. Romer, MD
    • Cell-matrix adhesion, tyrosine kinases and integrin signaling, endothelial cell injury
  • Karen Sfanos, PhD
    • Cellular and molecular pathology of prostate cancer
  • Kathryn R. Wagner, MD, PhD
    • Understanding and modulating the mechanisms of muscle growth and regeneration
  • Donald J Zack MD, PhD
    • Molecular biology and genetics of eye development and disease

Immunology, Virology, and Infectious Diseases

Neurobiology