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Faculty

  • Mark E. Anderson, MD, PhD
    • The role of the multifunctional Ca2+/calmodulin dependent protein kinase II (CaMKII) as a central signal contributing to myocardial dysfunction and arrhythmias
  • Mary Armanios, MD
    • Biology and genetics of telomere-mediated disease and age-related stem cell failure
  • Dwight Bergles, PhD
    • Synaptic Physiology: Glutamate Transporters and Glial Involvement in Neuronal Signaling
  • Seth Blackshaw, PhD
    • Identification of molecular pathways mediating neural development and survival
  • Ravit Boger, MD
    • Basic in vitro and translational studies of cytomegalovirus.
  • Ivan Borrello, MD
    • Development of an autologous graft vs. tumor effect early post-transplant that can be maintained by tumor-specific vaccinations
  • Frank Bosmans, PhD
    • Our lab investigates the functional mechanisms underlying voltage-gated sodium channel function in normal and disease states.
  • Peter A. Calabresi, MD
    • My laboratory focuses on mechanisms of autoimmune mediated injury to the central nervous system and the development of strategies to protect and repair myelin and axons
  • Arturo Casadevall, MD/PhD
    • The Casadevall laboratory studies pathogenic microbes to understand the molecular mechanisms responsible for virulence.
  • Thomas Clemens, PhD
    • Molecular mechanisms of insulin, IGF and GH on bond and skeletal muscle growth and function and regulation of angiogenesis in these organs*
  • Isabelle Coppens, PhD
    • Intracellular parasitism; host cell-pathogen interactions; Malaria; Toxoplasmosis
  • Andrea L. Cox, MD, PhD
    • Investigates the host immune response to chronic human viral infections, particularly HIV and hepatitis C virus (HCV)
  • Valina L. Dawson, PhD
    • Cell death and cell survival signaling pathways in models of stroke, and Parkinson's disease
  • Mark Donowitz, MD
    • Molecular biology and epithelial transport in signal transduction
  • Daniela Drummond-Barbosa, PhD
    • Control of ovarian stem cells and their differentiating progeny by diet, insulin, and other systemic signals; molecular mechanisms of meiotic maturation; Drosophila model system
  • Nick Flavahan, PhD
    • The overall goal of our laboratory is to investigate the cellular and molecular mechanisms and interactions that regulate blood vessel development, function and disease
  • Alan D. Friedman, MD
    • Myeloid leukemogenesis, transcriptional control of hematopoietic differentiation
  • Sandra B. Gabelli, PhD
    • Molecular mechanism of deregulation in cardiovascular, cancer and parasitic disease: structural and biochemical analysis
  • Luis Andres Garza, MD, PhD
    • Using skin as a model system, the Garza lab studies regenerative medicine using cell culture, mouse and interventional human trials to learn more about basic biology and new cures for the clinic.
  • Edward Harhaj, PhD
    • Regulation of signaling pathways in innate immunity and virus infection
  • Norman J. Haughey, PhD
    • Distinctive disease-oriented research program that address questions in basic neurobiology and in clinical neurology
  • Ahmet Hoke, MD, PhD
    • Our laboratory studies diseases of the peripheral nervous system focusing on neuroprotection and nerve regeneration.
  • Sanjay K. Jain, MD
    • My laboratory focuses on studying the pathogenesis of bacterial diseases, with a major focus on tuberculosis (TB).
  • Petros C. Karakousis, MD
    • Dr. Karakousis’ research is focused on elucidating the molecular mechanisms underlying bacterial persistence and antibiotic tolerance using Mycobacterium tuberculosis as the model organism.
  • David A. Kass, MD
    • Mechanisms underlying various forms of heart failure; developing novel treatments to combat it
  • Sabra L. Klein, PhD
    • Sex differences and the effects of hormones on immune responses to viral infections and vaccination
  • Alex L. Kolodkin, PhD
    • Cellular and molecular mechanisms that govern the establishment of neural connectivity
  • Chulan Kwon, PhD
    • Understanding the mechanisms governing heart generation and regeneration
  • Gyanu Lamichhane, PhD
    • We seek to understand the fundamental mechanisms, involving the peptidoglycan layer and non-coding RNA, used by Mycobacterium tuberculosis to survive, grow and cause disease
  • Mark Levis, MD
    • The development of molecularly targeted therapies for leukemia.
  • Tom Lloyd, MD, PhD
    • Studies the molecular and cellular mechanisms underlying neurodegenerative diseases of the peripheral nervous system
  • Svetlana Lutsenko, PhD
    • Integrative approach to the analysis of liver and brain pathology, Wilson’s disease, human copper metabolism, biochemistry and cell biology of transmembrane ion transport
  • Nicholas J. Maragakis, MD
    • Our laboratory is interested in mechanisms of disease progression in Amyotrophic Lateral Sclerosis, particularly in the context of astrocyte-mediated mechanisms of neurodegeneration.
  • William Matsui, MD
    • Cancer stem cells; developmental biology; hematopoiesis: clinical translation and clinical trials
  • Alan Meeker, PhD
    • Our lab focuses on abnormal telomere biology as it relates to cancer initiation and tumor progression, as well as cancer biomarker discovery and validation
  • Susan Michaelis, PhD
    • We study the premature aging disease progeria and nuclear lamin A processing, as well as protein aggregation and degradation in yeast and mammalian cells.
  • Lloyd S. Miller, MD, PhD
    • The research of my laboratory focuses on defining the mechanisms of protective innate and adaptive immune responses against bacterial infections in the skin and at other sites of infection.
  • Jeff Mumm, PhD
    • We study cellular and molecular mechanisms controlling the potential for neuronal regeneration using unique advantages afforded by the zebrafish system.
  • Brian O’Rourke, PhD
    • Mitochondrial ion channels, bioenergetics, and cardiac excitation-contraction coupling
  • Drew M. Pardoll, MD, PhD
    • Regulation of antigen specific T cell responses and studies approaches to modify these responses for immunotherapy
  • Peter L. Pedersen, PhD
    • • Cell energetics, its molecular and chemical basis and relationship to both Cancer and to the discovery of new therapies.
  • Kenneth Pienta, MD
    • Defining the tumor microenvironment of prostate cancer metastases and the development of new therapies for prostate cancer
  • Ryan C. Riddle, PhD
    • Role of Wnt signaling in bone growth and the influence of the skeleton on whole-body metabolism
  • Gregory J. Riggins, MD, PhD
    • The molecular basis of brain cancers and therapies directed against cancer-causing mutations and alterations.
  • Lewis H. Romer, MD
    • Cell-matrix adhesion, tyrosine kinases and integrin signaling, endothelial cell injury
  • Dipali Sharma, Ph.D.
    • Obesity-breast cancer molecular connection; Breast cancer prevention; endocrine therapy resistance
  • Donald Small, MD, PhD
    • Molecular biology of leukemia, molecularly targeted therapeutics, hematopoiesis, signal transduction
  • Charlotte Sumner, MD
    • Investigations of the genetic and molecular mechanisms of inherited peripheral nerve and motor neuron disorders
  • Phuoc T. Tran, MD, PhD
    • Mouse models of epithelial-mesenchymal transition (EMT) and oncogene addiction in lung, prostate and liver cancer; pre-clinical and clinical radiosensitizers
  • Fengyi Wan, PhD
    • Signal transduction and gene regulation in immune responses and cancer
  • Srinivasan (Vasan) Yegnasubramanain
    • The Yegnasubramanian lab is focused on understanding the complex interplay between genetic and epigenetic alterations in carcinogenesis and disease progression, and on exploiting this understanding in developing novel biomarkers for diagnosis and risk stratification as well as in identifying targets for therapeutic intervention
  • Lei Zheng, MD, PhD
    • Understanding the mechanistic roles of tumor microenvironment in cancer development, metastasis and antitumor immune response