|Education||BA, Washington University at St. Louis|
|Current Position||Clinical Research Associate|
Mt. Sinai Medical Center Miami Beach
The role of Keratin 17 in cell signaling
I am currently studying keratins, a type of intermediate filament, and their functions in cell growth signaling. Specifically, I am interested in deciphering the role that Keratin 17 (K17) play in the mTOR pathway. It was previously hypothesized that phosphorylated K17 may increase protein translation by interacting with 14-3-3σ, which negatively regulates the Tuberin/Hamarin complex, and thus releasing the inhibitory effect on mTOR. Up to date, the upstream kinase responsible for phosphorylating K17 has not been determined although Akt is a good candidate for various reasons. My project will focus on identifying the upstream signaling events that result in the K17 phosphorylation.