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Will Hendricks

Class 2005
Education BA, Arizona State Unviersity
Email
Mentor

Dr. Ken Kinzler

Current Position Assistant Professor
Location

Translational Genomics Research Institute

Research Interests

In Vitro Allele Separation: Improved Template Preparation for Downstream Genetic Analyses
When performing germline mutation analysis for diagnosis of dominantly inherited genetic disorders it is desirable to separate the diseased allele from the wild-type allele. In such diseases mutations only occur in one allele and are often undetectable by standard genomic DNA sequencing either because the mutant allele is masked by the wild-type allele or because the mutant allele is of a class not detectable by standard sequencing (e.g. large deletions or rearrangements). I’m developing an allele-separation assay to enhance the sensitivity of germline mutation detection. This technique may also be useful for template preparation in a variety of genetic studies such as genome-wide association studies and the cloning of translocations

Publications

Yang J, Hendricks W, Liu G, McCaffery JM, Kinzler KW, Huso DL, Vogelstein B, Zhou S.  A nanoparticle formulation that selectively transfects metastatic tumors in mice.  Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14717-22. doi: 10.1073/pnas.1313330110. Epub 2013 Aug 19. PMID:23959886

Schmidt-Kittler O, Zhu J, Yang J, Liu G, Hendricks W, Lengauer C, Gabelli SB, Kinzler KW, Vogelstein B, Huso DL, Zhou S.  PI3Kα inhibitors that inhibit metastasis.  Oncotarget. 2010 Sep;1(5):339-48.  PMID:21179398