|Education||BS, University of Maryland, College Park|
Hepatitis C virus (HCV) infects approximately 185 million people worldwide. Acute and chronic HCV infection is largely asymptomatic, but over time can progress from fibrosis to liver cirrhosis and hepatocellular carcinoma in chronically infected individuals. Although host immune responses often fail to clear HCV, there are individuals who spontaneously clear multiple HCV infections. Clearance of HCV is associated with the development of a cross-reactive antibody response, indicating that broadly-neutralizing antibodies may play a key role in immune control of HCV infection. My project aims to define the mechanisms by which neutralizing antibodies clear HCV infection.