Prevention of HIV-1 transmission from women to infants
HIV-1 is genetically heterogeneous, with different subtypes in different regions of the world. In addition, HIV viruses in a single individual are genetically diverse and evolve rapidly with antiretroviral drug selection. Dr. Susan Eshleman’s laboratory investigates the impact of this diversity on HIV infection. In particular, we study the impact of HIV-1 diversity on the emergence of drug resistance in the setting of treatment with antiretroviral drugs and use of antiretroviral drugs to prevent transmission of HIV-1 from women to their infants.