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Steven Wang

Class 2010
Education BA, University of Pennsylvania

Dr. Carol Greider

Research Interests

Telomeres are hexameric sequences at the ends of chromosomes that protect the chromosome from damage. Short telomeres are the cause of many telomere-associated diseases, such as Dyskeratosis Congenita. My goal is to elucidate the mechanisms underlying telomere length homeostasis, and their physiological implications. I will use high-throughput shRNA screening to discover novel pathways and proteins involved in this process. Furthermore, I will utilize the telomerase knockout mouse and bone marrow transplant model to evaluate the role of short telomeres and telomerase in hematopoiesis and stem cell self-renewal.