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Steve Lu

Class 2014
Education BS, University of Texas Austin
Email stevelu@jhmi.edu
Mentor

Dr. Bert Vogelstein

Research Interests

In cancer patients, the immunosuppressive environment has been well documented yet not fully characterized. A heterogeneous population of immature cells, myeloid-derived suppressor cells (MDSCs) can suppress T cell responses, promote tumor progression and angiogenesis as well as metastasis. However, these cells lack distinct markers and therefore make them difficult to study and evaluate in humans. Furthermore, the mechanisms by which they perform their functions are not well defined. By better identifying and understanding the mechanisms of MDSCs, we are hoping to develop novel approaches to target these cells for efficient tumor control.