EPA genes and Candida glabrata
Candida glabrata is emerging as a frequent, drug resistant infection in patients. The Cormack lab studies the pathogenicity of C. glabrata. In particular, primary focus is on Epithelial Adhesion (EPA) genes. Situated in the subtelomeric region, EPA genes are subject to differential silencing in vitro and during infections. The goals are to clarify the silencing mechanisms in C. glabrata and to look for the patterns of gene expression during infection, in hopes of identifying stimuli that overcome gene silencing.