|Education||DVM, University of Wisconsin Madison|
Fundamental to the establishment and maintenance of mammalian pregnancy are steroid hormones, including estrogens, progesterone, and human chorionic gonadotropin. Circulating concentrations of these hormones increase dramatically during pregnancy and help to orchestrate immunologic changes that are necessary for fetal tolerance. In the context of certain viral infections, however, these enhanced tolerogenic immune responses may impair host defenses, leading to delayed viral clearance and/or enhanced virus dissemination. My thesis work is aimed at characterizing in vivo the role of hormone-driven immune modulation in altering pathogenesis following infection with different classes of viruses, including both influenza virus and Zika virus.
- Hall OJ, Limjunyawong N, Vermillion MS, Robinson DP, Mitzner W and Klein SL. Progesterone protects against influenza by upregulating amphiregulin to promote recovery in females. 2016. PloS Pathog. (in press).
- Metcalf Pate KA, Pohlmeyer CW, Walker-Sperling VE, Foote JB, Najarro KM, Cryer CG, Salgado M, Gama L, Engle EL, Shirk EN, Queen SE, Chioma S, Vermillion MS, Bullock B, Li M, Lyons CE, Adams RJ, Zink MC, Clements JE, Mankowski JL, and Blankson JN. A murine viral outgrowth assay to detect residual HIV-1 in patients with undetectable viral loads. 2015. J Infect Dis.