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Megan Heimann

Class 2014
Education BA, Goucher College
Email mheiman2@jhmi.edu
Mentor

Dr. Ivan Borrello

Research Interests

Our lab is interested in various strategies to improve anti-tumor immunity against multiple myeloma. My project focuses on strategies to improve the anti-tumor effects of marrow-infiltrating lymphocytes (MILs), tumor specific T-cells that inhabit the bone marrow. Previous work within the lab has shown that MILs, when compared to peripheral blood lymphocytes (PBLs), possess very different functional and phenotypic characteristics due to their unique microenvironment. MILs have also been shown to have enhanced anti-tumor effects in adoptive transfer therapy for the treatment of multiple myeloma. The goal of my project is to exploit these differences and further characterize what makes MILs unique to improve upon existing treatment strategies.