|Education||BA, Clark University|
Dr. Jim Herman
|Current Position||Clinical Assistant Professor|
Boston University School of Public Health
Transcriptional repression and epigenetic silencing
Transcriptional repression is normally a dynamic and tightly controlled process. Over-expression of transcriptional repressors down-regulates target gene transcription, and aberrant repression of tumor suppressor genes, including genes that counteract angiogenesis, may contribute to tumorigenesis. My project aims to characterize the molecular mechanism by which transcriptional repressor Id1 down-regulates its anti-angiogenic factor TSP-1 target, hypothesizing that prolonged TSP-1 repression may signal epigenetic machinery to deposit histone marks and DNA hypermethylation, leading to heritable gene silencing in melanoma.