|Education||DVM, The Ohio State University|
|Current Position||Research Faculty|
Johns Hopkins School of Medicine
Human immunodeficiency virus-associated peripheral neuropathy (HIV-PN) is currently the most frequent neurologic complication of HIV infection. It affects approximately 40-60% of individuals living with HIV, including those receiving effective combination antiretroviral therapy. The most common clinical manifestation of HIV-PN is distal sensory polyneuropathy (DSP), a progressive and often painful syndrome characterized by bilateral numbness, tingling, and burning sensations most pronounced in the feet and lower legs. While HIV-PN is not a life-threatening condition, the debilitating pain and parasthesias associated with the disease can significantly impair patients’ quality of life, and there is a strong need for novel analgesic therapies that more specifically target key factors in the generation of neuropathic pain. Numerous recent studies have implicated certain isoforms of voltage-gated sodium (NaV) channels, namely NaV 1.7,1.8, and 1.9, as essential players in a wide range of painful clinical conditions and analogous animal models. These channels are predominantly expressed by neurons of the peripheral nociceptive system and are attractive targets for the development of new analgesic therapies with minimal CNS side effects. My project aims to investigate the roles of these nociceptive NaV channels in somatosensory signaling using an SIV-infected pigtailed macaque model of HIV-PN. I am also working to design a heterologous expression system that would allow in-depth molecular and electrophysiological characterization of the macaque NaV channels and provide a platform for high-throughput screening of potential modulating compounds.
- Mangus LM, Dorsey JL, Laast VA, Hauer P, Queen SE, Adams RJ, McArthur JC, Mankowski JL. 2015. Neuroinflammmation and virus replication in the spinal cord of SIV-infected macaques. Journal of Neuropathology and Experimental Neurology. 74(1): 38-47.
- Mangus LM, Dorsey JL, Laast VA, Ringkamp M, Ebenezer GJ, Hauer P, Mankowski JL. 2014. Unraveling the pathogenesis of HIV peripheral neuropathy: insights from an SIV/macaque model. ILAR Journal. 54(3): 296-303.
- Dorsey JL, Mangus LM, Hauer P, Ebenezer GJ, Queen SE, Laast VA, Adams RJ, Mankowski JL. 2015. Persistent peripheral nervous system damage in a simian immunodeficiency virus-infected macaques receiving antiretroviral therapy. Journal of Neuropathology and Experimental Neurology. 74(11): 1053-60.
- Beck SE, Queen SE, Witwer KW, Metcalf Pate KA, Mangus LM, Gama L, Adams RJ, Clements JE, Zink MC, Mankowski JL. 2015. Paving the path to HIV neurotherapy: predicting SIV CNS disease. European J Pharmacology. 15;759:303-12.
- Dorsey JL, Mangus LM, Oakley JD, Beck SE, Kelly KM, Queen SE, Metcalf Pate KA, Adams RJ, Marfurt CF, Mankowsky JL. 2014. Loss of corneal sensory nerve fibers in SIV-infected macaques: an alternate approach to investigate HIV-induced PNS damage. American Journal of Pathology. 184(6):1652-1659.