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Kelly Metcalf Pate, DVM

Class 2008
Education DVM, Purdue University

Dr. Joseph Mankowski

Current Position Assistant Professor

Johns Hopkins University School of Medicine

Research Interests

Immunologic role that activated platelet play during acute SIV/HIV infection

The prevalence of HIV-associated neurocognitive disorders has risen even in the face of significant advances in our knowledge of HIV/AIDS. Platelets are tiny anucleate blood cells that play a significant role in both hemostasis and innate immunity. We have found that platelets are activated during acute infection in our SIV-infected macaque model, and the Retrovirus lab has been able to demonstrate that the magnitude of platelet decline during late infection is predictive for the development of CNS disease in both macaques and humans. I am interested in the immunologic role that activated platelet play during acute SIV/HIV infection and in the pathogenesis of CNS disease.


Dr. Pate’s Google Scholar Page

Metcalf Pate KA, Pohlmeyer CW, Walker-Sperling VE, Foote JB, Najarro KM, Cryer CG, Salgado M, Gama L, Engle EL, Shirk EN, Queen SE, Chioma S, Vermillion MS, Bullock B, Li M, Lyons CE, Adams RJ, Zink MC, Clements JE, Mankowski JL, Blankson JN. A Murine Viral Outgrowth Assay to Detect Residual HIV Type 1 in Patients With Undetectable Viral Loads. J Infect Dis. 2015 Nov 1;212(9):1387-96. doi: 10.1093/infdis/jiv230. Epub 2015 Apr 15. PMID:25883388

Beck SE, Queen SE, Witwer KW, Metcalf Pate KA, Mangus LM, Gama L, Adams RJ, Clements JE, Christine Zink M, Mankowski JL. Paving the path to HIV neurotherapy: Predicting SIV CNS disease. Eur J Pharmacol. 2015 Jul 15;759:303-12. doi: 10.1016/j.ejphar.2015.03.018. Epub 2015 Mar 24. Review. PMID:25818747

Dorsey JL, Mangus LM, Oakley JD, Beck SE, Kelly KM, Queen SE, Metcalf Pate KA, Adams RJ, Marfurt CF, Mankowski JL. Loss of corneal sensory nerve fibers in SIV-infected macaques: an alternate approach to investigate HIV-induced PNS damage. Am J Pathol. 2014 Jun;184(6):1652-9. doi: 10.1016/j.ajpath.2014.02.009. Epub 2014 May 12. PMID: 24828391

Kelly KM, Tocchetti CG, Lyashkov A, Tarwater PM, Bedja D, Graham DR, Beck SE, Metcalf Pate KA, Queen SE, Adams RJ, Paolocci N, Mankowski JL. CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV. J Am Heart Assoc. 2014 Apr 2;3(2):e000874. doi: 10.1161/JAHA.114.000874. PMID:24695652

Baxter VK, Shaw GC, Sotuyo NP, Carlson CS, Olson EJ, Zink MC, Mankowski JL, Adams RJ, Hutchinson EK, Metcalf Pate KA. Serum albumin and body weight as biomarkers for the antemortem identification of bone and gastrointestinal disease in the common marmoset. PLoS One. 2013 Dec 6;8(12):e82747. doi: 10.1371/journal.pone.0082747. eCollection 2013. PMID:24324827

Metcalf Pate KA, Lyons CE, Dorsey JL, Queen SE, Adams RJ, Morrell CN, Mankowski JL. TGFβ-Mediated Downregulation of Thrombopoietin Is Associated With Platelet Decline in Asymptomatic SIV Infection. J Acquir Immune Defic Syndr. 2014 Apr 15;65(5):510-6. doi: 10.1097/QAI.0000000000000048. PMID:24220290

Kelly KM, Beck SE, Metcalf Pate KA, Queen SE, Dorsey JL, Adams RJ, Avery LB, Hubbard W, Tarwater PM, Mankowski JL. Neuroprotective maraviroc monotherapy in simian immunodeficiency virus-infected macaques: reduced replicating and latent SIV in the brain. AIDS. 2013 Nov 28;27(18):F21-8. doi: 10.1097/QAD.0000000000000074.PMID:24051706

Metcalf Pate KA, Lyons CE, Dorsey JL, Shirk EN, Queen SE, Adams RJ, Gama L, Morrell CN, Mankowski JL. Platelet activation and platelet-monocyte aggregate formation contribute to decreased platelet count during acute simian immunodeficiency virus infection in pig-tailed macaques. J Infect Dis. 2013 Sep;208(6):874-83. doi: 10.1093/infdis/jit278. Epub 2013 Jul 11. PMID:23852120

Metcalf Pate KA, Mankowski JL. HIV and SIV Associated Thrombocytopenia: An Expanding Role for Platelets in the Pathogenesis of HIV. Drug Discov Today Dis Mech. 2011 Summer;8(1-2):e25-e32. Epub 2011 Nov 9. PMID: 22577463