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Kelly Kyker-Snowman

Class 2013
Education MS, University of Rochester
Email kkykers1@jhmi.edu
Mentor

Dr. Ben Park

Research Interests

Triple negative breast cancers and high grade serous ovarian cancers are highly aggressive cancer subtypes with similarly heterogeneous molecular profiles that share high mortality rates and a dearth of targeted therapies. The objective of my project is to expand applications of personalized and specific therapies in current clinical use to these subtypes by genome editing and characterization of immortalized epithelial cell line models of each.

Publications

Chu D, Paoletti C, Gersch C, VanDenBerg D, Zabransky D, Cochran R, Wong HY, Valda Toro P, Cidado J, Croessmann S, Erlanger B, Cravero K, Kyker-Snowman K, Button B, Parsons H, Dalton WB, Gillani R, Medford A, Aung K, Tokudome N, Chinnaiyan A, Schott AF, Robinson DR, Jacks K, Lauring J, Hurley PJ, Hayes DF, Rae JM, Park BH. ESR1 mutations in circulating plasma tumor DNA from metastatic breast cancer patients. Clin Cancer Res. 2015 Aug 10. pii: clincanres.0943.2015. PMID 26261103

Zabransky DJ, Yankaskas CL, Cochran RL, Wong HY, Croessmann S, Chu D, Kavuri SM, Red Brewer M, Rosen DM, Dalton WB, Cimino-Mathews A, Cravero K, Button B, Kyker-Snowman K, Cidado J, Erlanger B, Parsons HA, Manto KM, Bose R, Lauring J, Arteaga CL, Konstantopoulos K, Park BH. HER2 missense mutations have distinct effects on oncogenic signaling and migration. Proc Natl Acad Sci U S A. 2015 Oct 27. pii: 201516853.PMID: 26508629

 

Croessmann S, Wong HY, Zabransky DJ, Chu D, Mendonca J, Sharma A, Mohseni M, Rosen DM, Scharpf RB, Cidado J, Cochran RL, Parsons HA, Dalton WB, Erlanger B, Button B, Cravero K, Kyker-Snowman K, Beaver JA, Kachhap S, Hurley PJ, Lauring J, Park BH.NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability.Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11583-8. doi: 10.1073/pnas.1503683112. Epub 2015 Aug 31. PMID:26324937