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Katherine LaClair

Class 2010
Education BS, Drew University
Email klaclai1@jhmi.edu
Mentor

Dr. Phil Wong

Current Position Postdoctoral fellow
Location

German Center for Neurodegenerative Diseases

Research Interests

I am interested in contributing to the development of disease-modifying therapeutics for Alzheimer’s disease (AD) by addressing etiologic diversity in specific emerging sub-populations of patients. My current work uses transgenic modeling and molecular biology techniques to investigate the potential contribution of disease-related pathologies to the etiology of Alzheimer’s disease. My current focus is on the RNA-binding protein TDP43, which is observed in cytoplasmic inclusions with accompanying loss of nuclear expression in sub-populations of patients with Alzheimer’s, amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD). Using transgenic mouse models of amyloidosis and samples from human patients, I am investigating the potential involvement of this loss of TDP43 in the etiology and progression of Alzheimer’s disease.