Characterization of Inflammatory Stimuli and Lymphocyte Populations in the Prostates of Patients Undergoing Radical Retropubic Prostatectomy
Many cancers, like prostate cancer, for which no infectious agent has been identified, are commonly found to contain inflammatory cell infiltrates or are linked to inflammatory conditions (such as prostatitis). In fact, the frequent finding of inflammatory cell infiltrates in the prostates of men undergoing radical retropubic prostatectomy (RRP) to treat prostate cancer has led to the theory that prostate cancer may also be an inflammation-associated disease. Even with the surmounting evidence of bacterial and/or viral presence in the human prostate, it is unknown whether (1) bacterial and/or viral infection is responsible for the prostatic inflammatory infiltrates known to co-exists with many human prostate cancers or (2) inflammation in the human prostate is causative, consequential, or insignificant in prostate cancer development. My thesis is aimed at characterizing the inflammatory cells that infiltrate the prostates of RRP patients and determining potential stimuli for inflammatory cell recruitment.