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Kaitlyn Sadtler

Class 2012
Education BS, University of Maryland Baltimore County
Email ksadtle3@jhmi.edu
Mentor

Dr. Jennifer Elisseeff

Current Position Postdoctoral fellow
Location

Johns Hopkins University

Research Interests

The tissue microenvironment has profound effects on the immune system’s response to a foreign body such as a pathogen or a biomaterial implant. My research focuses on how this microenvironment changes a host response to regenerative scaffolds used in tissue engineering, and how we can manipulate that immune environment to promote tissue growth and regeneration. Through the use of decellularized extracellular matrix (ECM) scaffolds, we are able to investigate how immune cells interact with these matrices and how the interplay between the scaffold and cells create the host response. This response is dependent upon the tissue from which the ECM scaffold is derived, as well as the location within the host that the scaffold is placed. In this manner, our ECM scaffolds can be viewed as both a biomaterial in a pre-existing tissue microenvironment (implantation site) as well as an engineered environment (tissue or organ from which the ECM is derived) that alter the immune response. With a more thorough understanding of the effect of the scaffold on the immune polarization, as well as the effect of the immune response on the regenerative capabilities of the graft, we will be able to apply a more rational scaffold design to promote immune-mediated tissue regeneration.

Publications

Beachley VZ, Wolf MT, Sadtler K, Manda SS, Jacobs H, Blatchley MR, Bader JS, Pandey A, Pardoll D, Elisseeff JH. Tissue matrix arrays for high-throughput screening and systems analysis of cell function. Nat Methods. 2015 Dec;12(12):1197-204. doi: 10.1038/nmeth.3619. Epub 2015 Oct 19. PMID:26480475