|Education||BS, Case Western Reserve University|
Dr. Charles Rudin
|Current Position||Assistant Professor|
Memorial Sloan Kettering Cancer Center
Determinants of Seneca Valley Virus tropism for neuroendocrine cancers
Description: Seneca Valley Virus (SVV-001) is a novel oncolytic RNA virus with selective tropism for cancers with neuroendocrine features. The molecular determinants and mechanism of infectivity for SVV-001 have yet to be elucidated. The aim of this project is to identify these determinants of infectivity to be used as clinical biomarkers to select patients with neuroendocrine cancers who will have the highest therapeutic benefit from the virus. Future studies will focus on SVV-001 treatment in combination with immune suppression in animal models of neuroendocrine cancers.