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Janelle Rowell

Class 2008
Education BS, North Carolina Central University
Email
Mentor

Dr. David Kass

Current Position ORISE Postdoctor Fellow
Location

FDA

Research Interests

Defining therapeutic targets to inhibit pathologic hypertrophy

Heart failure is defined as the inability of the heart to meet the demands of the body. In many instances, heart failure results from pathologic ventricular hypertrophy which is followed by cardiac dilation. Previously, my lab reported that the activation of the protein kinase G (PKG) pathway blocks hypertrophic signaling and leads to reverse remodeling in mouse models. My thesis work will focus on defining the downstream targets of PKG signaling, as well as identifying novel therapeutic targets.