HOX genes in Breast Cancer
The Hox network consists of 39 transcription factors divided into 4 clusters (A, B, C and D). They control not only morphogenesis during development, but also cell differentiation and proliferation, and therefore may play a role in oncogenesis, such as in breast cancer. We and others have found that many of the HOX genes are misexpressed in human breast primary tumors and metastatic samples. Our goal is to identify the role and what control the deregulation of these HOX genes during breast cancer initiation and progression.