|Education||MBBS (K. S. Hegde Medical Academy, Mangalore), MMST (IIT Kharagpur)|
NHE6 and NHE9 are endosomal subtypes of the Na+/H+ exchanger gene superfamily (eNHE) that have recently been linked to multiple neurodevelopmental and neuropsychiatric disorders, including autism, severe X-linked intellectual disability (XLID), epilepsy, addiction, multiple sclerosis, attention deficit hyperactivity disorder (ADHD), and most recently, to Alzheimer’s Disease. By providing a leak pathway for protons pumped by the V-ATPase, eNHE regulate luminal pH and cation (Na+,K+) content in early and recycling endosomal compartments to control vesicular traffic and protein turnover. Although NHE6 and NHE9 are abundantly expressed in brain, particularly in the hippocampus and cerebral cortex, their role in neuronal physiology is currently unknown. The goal of my thesis is to establish a functional link between eNHE and Alzheimer’s disease through a mechanistic understanding of the role of endosomal pH in amyloid pathologies.
- Prasad H, Rao R. The Na+/H+ exchanger NHE6 modulates endosomal pH to control processing of amyloid precursor protein in a cell culture model of Alzheimer disease. J Biol Chem. 2015;290(9):5311-27. doi: 10.1074/jbc.M114.602219. PMID 25561733
- Prasad H, Rao R. Applying knowledge of autism to brain cancer management: what do we know? Future Oncol. 2015;11(13):1847-50. doi: 10.2217/fon.15.93.PMID 26161920
- Kondapalli KC, Prasad H, Rao R. An inside job: how endosomal Na(+)/H(+) exchangers link to autism and neurological disease. Front Cell Neurosci. 2014;8:172. doi: 10.3389/fncel.2014.00172. PMID 25002837
- Kondapalli KC, Llongueras JP, Capilla-González V, Prasad H, Hack A, Smith C, Guerrero-Cázares H, Quiñones-Hinojosa A, Rao R. A leak pathway for luminal protons in endosomes drives oncogenic signalling in glioblastoma. Nat Commun. 2015;6:6289. doi: 10.1038/ncomms7289. PMID 25662504