Skip links

Main navigation

Han Sun

Class 2010
Education BS, Nanyang Technological University
Email hsun21@jhmi.edu
Mentor

Dr. Min Li

Current Position Postdoctoral Fellow
Location

City of Hope

Research Interests

Discovery of novel modulators of potassium channels

Potassium channels are one of the most widely distributed types of ion channels that form selective pores across cell membrane. They play critical roles in variety of biological processes. For instance, in excitable cells, transient passage of potassium contributes to the maintenance of resting membrane potential and regulation of action potentials. Malfunction of potassium channels has been associated with diverse neurological disorders, cardiac abnormalities and metabolic diseases. Therefore, discovery and characterization of specific modulators of these channels are of great interest. In our lab, we integrate traditional and modern techniques to search for novel modulators and dissect their functions. These studies may greatly facilitate mechanistic investigation and therapeutic development for potassium channels.

Publications

Sun H, Luo L, Lal B, Ma X, Chen L, Hann CL, Fulton AM, Leahy DJ, Laterra J, Li M.  A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis.  Nat Commun. 2016 Feb 4;7:10339. doi: 10.1038/ncomms10339.PMID:26842342

Sun H, Li M.   Antibody therapeutics targeting ion channels: are we there yet?   Acta Pharmacol Sin. 2013 Feb;34(2):199-204. doi: 10.1038/aps.2012.202. PMID:23381110