|Education||BS, Nanyang Technological University|
Dr. Min Li
|Current Position||Postdoctoral Fellow|
City of Hope
Discovery of novel modulators of potassium channels
Potassium channels are one of the most widely distributed types of ion channels that form selective pores across cell membrane. They play critical roles in variety of biological processes. For instance, in excitable cells, transient passage of potassium contributes to the maintenance of resting membrane potential and regulation of action potentials. Malfunction of potassium channels has been associated with diverse neurological disorders, cardiac abnormalities and metabolic diseases. Therefore, discovery and characterization of specific modulators of these channels are of great interest. In our lab, we integrate traditional and modern techniques to search for novel modulators and dissect their functions. These studies may greatly facilitate mechanistic investigation and therapeutic development for potassium channels.
Sun H, Luo L, Lal B, Ma X, Chen L, Hann CL, Fulton AM, Leahy DJ, Laterra J, Li M. A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis. Nat Commun. 2016 Feb 4;7:10339. doi: 10.1038/ncomms10339.PMID:26842342
Sun H, Li M. Antibody therapeutics targeting ion channels: are we there yet? Acta Pharmacol Sin. 2013 Feb;34(2):199-204. doi: 10.1038/aps.2012.202. PMID:23381110