|Education||BA, Bryn Mawr College|
|Current Position||Medical School|
University of Maryland Medical School
My dissertation is focused on elucidating the cellular and molecular mechanism of regulatory pathways governing deltaF508-CFTR. The deltaF508 mutation is the most common mutation among CF (Cystic Fibrosis) patients. Approximately 90% of the total patient population carry one copy and 50% are homozygous. The mutation is characterized by a misfolded CFTR protein which is degraded early on by the proteasome. My particular interest lies with the CAL (CFTR-Associated Ligand) protein, a PDZ domain containing protein that is critical for WT-CFTR trafficking and may play an important role in deltaF508-CFTR regulation. Data has shown that knockdown of the CAL protein can alter trafficking and maturation of deltaF508-CFTR. Our goal is to investigate the effects of CAL on deltaF508-CFTR, and elucidate the mechanism by which it regulated deltaF508-CFTR surface expression.
- Dogan I, Kawabata S, Bergbower E, Gills JJ, Ekmekci A, Wilson W 3rd, Rudin CM, Dennis PA. SOX2 expression is an early event in a murine model of EGFR mutant lung cancer and promotes proliferation of a subset of EGFR mutant lung adenocarcinoma cell lines. Lung Cancer. 2014 Jul;85(1):1-6. doi: 10.1016/j.lungcan.2014.03.021. Epub 2014 Mar 29. PMID: 24746758
- Romano JD, Sonda S, Bergbower E, Smith ME, Coppens I. Toxoplasma gondii salvages sphingolipids from the host Golgi through the rerouting of selected Rab vesicles to the parasitophorous vacuole. Mol Biol Cell. 2013 Jun;24(12):1974-95.. Epub 2013 Apr 24.PMID:23615442
- Rudin CM, Durinck S, Stawiski EW, Poirier JT, Modrusan Z, Shames DS, Bergbower EA, Guan Y, Shin J, Guillory J, Rivers CS, Foo CK, Bhatt D, Stinson J, Gnad F, Haverty PM, Gentleman R, Chaudhuri S, Janakiraman V, Jaiswal BS, Parikh C, Yuan W, Zhang Z, Koeppen H, Wu TD, Stern HM, Yauch RL, Huffman KE, Paskulin DD, Illei PB, Varella-Garcia M, Gazdar AF, de Sauvage FJ, Bourgon R, Minna JD, Brock MV, Seshagiri S. Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Nat Genet. 2012 Oct;44(10):1111-6.. Epub 2012 Sep 2. PMID:22941189
- Seizure tests distinguish intermittent fasting from the ketogenic diet. Hartman AL, Zheng X, Bergbower E, Kennedy M, Hardwick JM. Epilepsia. 2010 Aug;51(8):1395-402. Epub 2010 Apr 30. PMID:20477852