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Brian Mears

Class 2014
Education BS, University of Maryland College Park
Email bmears1@jhmi.edu
Mentor

Dr. Andy Feinberg

Research Interests

Epigenetics is the study of heritable information during cell division other than the DNA sequence per se. Chromatin structure is a fundamental part of epigenetic information and yet due to its difficult nature to study it remains poorly understood in comparison to DNA methylation. A new method called the assay of transposase-accessible chromatin sequencing (ATAC-Seq) allows for fast and easy probing of active (open, euchromatic) and inactive (closed, heterochromatic) regions of the genome. Using adaptations of this new method we aim to elucidate the differences in chromatin structure between normal and cancer cells, relate them to changes in DNA methylation, and patient outcomes to therapy.