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Angela Brice

Class 2003
Education DVM, Tuskegee University

Dr. Chris Zink

Current Position Laboratory Animal Pathologist, Assistant Professor

University of Pennsylvania

Research Interests

Minocycline Inhibits SIV Replication In SIV-Infected Macrophages And Lymphocytes Of Macaques
World Health Organization figures indicate that in 2003 over 40 million adults and children were infected with HIV globally. Current anti-AIDS therapies are expensive, require complex dosing regimens and have significant side effects and toxicity. Previous studies have demonstrated that minocycline, a safe, readily available, inexpensive, semisynthetic tetracycline derivative suppresses replication of HIV and SIV in macrophages and lymphocytes, the major hosts for productive replication of the viruses in the CNS, in a dose-dependant manner. HIV replication in primary human lymphocytes has been shown to be dependant on expression of the mitogen-activated protein kinase p38. Interestingly, suppression of SIV replication in minocycline-treated SIV-infected primary lymphocytes likely occurs via a p38-dependant pathway, while in macrophages it is p38 independent. The purpose of these studies is to define the mechanisms by which minocycline inhibits virus replication in these cells and to examine the stage of virus replication at which minocycline acts. Minocycline is a safe, readily available antibiotic that should be investigated as an anti-HIV therapeutic.