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Alexis Norris

Class 2010
Education BS, Millersville University

Dr. Jim Eshleman

Current Position Post Doctoral Fellow

Kennedy Krieger Institute

Research Interests

Pancreatic cancer is one of the deadliest forms of cancer, with a dismal 5-year survival below 5%. Approximately 10% of cases are thought to have a familial basis, with the majority of those (>80%) having unidentified germline mutations. Recently, our group identified two new pancreatic cancer familial susceptibility genes – PALB2 and ATM. These findings led to the opportunity to identify at-risk individuals and develop targeted therapy. I am interested in identifying additional susceptibility genes in a panel of familial pancreatic cancer cell lines, determining how they contribute to carcinogenesis, and exploiting those genetic defects for more effective therapy options.