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Alexis Norris

Class 2010
Education BS, Millersville University
Email anorris8@jhmi.edu
Mentor

Dr. Jim Eshleman

Current Position Post Doctoral Fellow
Location

Kennedy Krieger Institute

Research Interests

Pancreatic cancer is one of the deadliest forms of cancer, with a dismal 5-year survival below 5%. Approximately 10% of cases are thought to have a familial basis, with the majority of those (>80%) having unidentified germline mutations. Recently, our group identified two new pancreatic cancer familial susceptibility genes – PALB2 and ATM. These findings led to the opportunity to identify at-risk individuals and develop targeted therapy. I am interested in identifying additional susceptibility genes in a panel of familial pancreatic cancer cell lines, determining how they contribute to carcinogenesis, and exploiting those genetic defects for more effective therapy options.