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Alexandra Borodovsky

Class 2009
Education BS, University of Puget Sound
Email aborodo1@jhmi.edu
Mentor

Dr. Greg Riggins

Current Position Senior Scientist
Location

AstraZeneca

Research Interests

Gliomas are a collection of nervous system tumors arising from glial cells such as astrocytes and oligodendrocytes.
The most deadly and aggressive of these gliomas is Glioblastoma Multiforme (GBM), with a median survival time of approximately 15 months from the time of diagnosis. Recent sequencing efforts of low grade gliomas and GBM tumors have revealed a frequent single point mutation in isocitrate dehydrogenase 1 (IDH1) which confers neomorphic activity to the enzyme. My project focuses on exploring novel therapeutic strategies to target the IDH1 mutation in gliomas.

Publications

Borodovsky A, Meeker AK, Kirkness EF, Zhao Q, Eberhart CG, Gallia GL, Riggins GJ. A model of a patient-derived IDH1 mutant anaplastic astrocytoma with alternative lengthening of telomeres.  J Neurooncol. 2015 Feb;121(3):479-87. doi: 10.1007/s11060-014-1672-2. Epub 2014 Dec 4. PMID:25471051

Borodovsky A, Seltzer MJ, Riggins GJ. Altered cancer cell metabolism in gliomas with mutant IDH1 or IDH2. Curr Opin Oncol. 2012 Jan;24(1):83-9. doi: 10.1097/CCO.0b013e32834d816a. Review. PMID: 22080945

Borodovsky A, Salmasi V, Turcan S, Fabius AW, Baia GS, Eberhart CG, Weingart JD, Gallia GL, Baylin SB, Chan TA, Riggins GJ.  5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft. Oncotarget. 2013 Oct;4(10):1737-47. PMID: 24077805

Larsen AR, Bai RY, Chung JH, Borodovsky A, Rudin CM, Riggins GJ, Bunz F. Repurposing the antihelmintic mebendazole as a hedgehog inhibitor. Mol Cancer Ther. 2015 Jan;14(1):3-13. doi: 10.1158/1535-7163.MCT-14-0755-T. Epub 2014 Nov 5. PMID: 25376612

Turcan S, Fabius AW, Borodovsky A, Pedraza A, Brennan C, Huse J, Viale A, Riggins GJ, Chan TA. Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.Oncotarget. 2013 Oct;4(10):1729-36. PMID:24077826

Kim J, Aftab BT, Tang JY, Kim D, Lee AH, Rezaee M, Kim J, Chen B, King EM, Borodovsky A, Riggins GJ, Epstein EH Jr, Beachy PA, Rudin CM. Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists.Cancer Cell. 2013 Jan 14;23(1):23-34. Epub 2013 Jan 3. PMID: 23291299