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Agnieszka (Aggie) Rucki

Class 2011
Education BS, Rutgers University
Email arucki1@jhmi.edu
Mentor

Dr. Elizabeth Jaffee

Dr. Lei Zheng

Current Position Research Program Coordinator
Location

Johns Hopkins University

Research Interests

Pancreatic Ductal Adenocarcinoma (PDA) is the 4th leading cause of cancer deaths in both men and women in the US. There has been very little progression in the development of treatments for PDA in the past decade, hence the need for new therapy is crucial. In order to improve the existing chemotherapy arsenal, we need to understand the biology of PDA better. Interestingly, 60 to 90 percent of pancreatic tumor mass is comprised of stroma, suggesting that tumor microenvironment may play an important role in cancer progression and metastasis.

Our lab identified Annexin A2 (ANXA2) as a protein that plays a role in metastasis and invasion of PDA. The expression and localization of ANXA2 changes with progression of pancreatic cancer; from low, mostly cytosolic expression in premalignant lesions; to high, plasma membrane expression in PDA. We have also showed that the translocation of ANXA2 to cell surface is phosphorylation dependent, specifically on Tyrosine 23 (Zheng L., et al. Tyrosine 23 phosphorylation-dependent cell-surface localization of Annexin A2 is required for invasion and metastases of pancreatic cancer. PLoS One. 2011; 6(4):e19390). The close proximity of plasma membrane ANXA2 to the tumor microenvironment is of interest to us, as it proposes a cross-talk between the stroma and cancer cells mediated by ANXA2.

My thesis project will focus on understanding specific signaling pathways within the tumor microenvironment and their role in regulation of ANXA2. This knowledge could then be utilized to develop novel therapeutic agents for treatment of pancreatic cancer.

Publications

  • Sequential treatment with a listeria-based vaccine and PD-1 blockade antibody improves survival in a murine model of pancreatic ductal adenocarcinoma. V. Kim · K. Foley · K. Soares · A. Rucki · P. Lauer · D. Brockstedt · C. Wolfgang · E. Jaffee · L. Zheng. HPB 18:e45-e46 · March 2016 DOI: 10.1016/j.hpb.2016.02.113

 

 

 

  • Targeting Sema3D in pancreatic cancer: A novel therapeutic strategy. Adrian Gerard Murphy · Jennifer Kleponis · Agnieszka Rucki · Elizabeth Jaffee · Lei Zheng · Kelly Foley. May 2015Conference: ASCO 2015, At Chicago, Volume: J Clin Oncol 33, 2015 (suppl; abstr 4129).