|SOM Address||646 Ross Research Building|
Tamara Flys 2002 – 2007
Jessica Church McDonough 2004 – 2009
The HIV viruses in an infected individual are genetically diverse and evolve at a rapid rate in response to selective pressures. Current studies in the laboratory are focused on understanding the impact of HIV viral diversity on viral fitness, antiretroviral drug susceptibility, pathogenesis of HIV infection,1. and HIV transmission. Most of our studies are performed in the context of national and international clinical trials of HIV treatment and prevention. This allows us to directly correlate our virologic findings with clinical parameters such as viral load, CD4 cell count, response to therapy, development of drug resistance after drug exposure, and HIV transmission. We also collaborate with commercial companies and other investigators to develop and validate methods for analysis of HIV for research and clinical management.
- Fogel J, Li Q, Taha TE, Hoover DR, Kumwenda NI, Mofenson LM, Kumwenda JJ, Fowler MG, Thigpen MT, and Eshleman SH. Initiation of antiretroviral treatment in women after delivery can induce multi-class drug resistance in breastfeeding HIV-infected infants. Clin Infect Dis. 2011; 52:1069–1076.
- Eshleman SH, Hudelson S, Redd AD, Wang L, Debes R, Chen YQ, Martens CA, Ricklefs SM, Selig EJ, Porcella SF, S Munshaw, SC Ray, Piwowar-Manning E, McCauley M, Hosseinipour MC, Kumwenda J, Hakim JG, Chariyalertsak S, de Bruyn G, Grinsztejn B, Kumarasamy N, Makhema J, Mayer KH, Pilotto J, Santos BR, Quinn TC, Cohen MS, and Hughes JP. Analysis of genetic linkage of HIV from couples enrolled in the HIV Prevention Trials Network 052 trial. J Infect Dis. 2011; 204:1918-1926.
- Cousins M, Ou S-S, Donnell D, and Eshleman SH. Impact of mutation type and amplicon characteristics on genetic diversity measures generated using a high-resolution melting diversity assay. J Molec Diagnosis. 2013. 15:130-137.
- James MM, Laeyendecker O, Sun J, Hoover DR, Mullis CE, Cousins MM, Coates T, Moore RD, Kelen GD, Fowler MG, Kumwenda JJ, Mofenson LM, Kumwenda NI, Taha TE, and Eshleman SH. Antibody maturation and viral diversification in HIV-infected women. PLoS One. 2013. 8(2): e57350.
- Laeyendecker O, Piwowar-Manning E, Fiamma A, Kulich M, Donnell D, Bassuk D, Mullis CE, Chin C, Vallari A, Hackett J, Jr., Clarke W, Marzinke M, Szekeres G, Gray G, Richter L, Mbwambo J, Chariyalertsak S, Chingono A, Celantano D, Morin SF, Sweat M, Coates T, and Eshleman SH. Estimation of HIV incidence in a large, community-based, randomized clinical trial: NIMH Project Accept (HIV Prevention Trials Network 043). 2013. PLoS One 8(7):e68349.