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Stephen B. Baylin, MD

Department Affiliations Oncology
Rank Professor
Office Phone 410-955-8506
Lab Phone
Fax 410-614-9884
Email sbaylin@jhmi.edu
SOM Address 544 Cancer Research Building I
Website
Students

Kurtis Bachman 1996 – 2000

Xiaobei Zeng 1996 – 2002

Virote Sriurangpong 1997 – 2001

Eric Nakakura 1998 – 2001

Sayaka Eguchi 1999 – 2006

Brian Reese 1999 – 2004

Jill Fahrner 2000 – 2004

Angela Ting 2001 – 2005

Kimberly Briggs 2002 – 2008

Kelly McGarvey 2002 – 2007

Eriko Greene Clements 2003 – 2011

David Wang 2003 – 2010

Hsing-Chen Tsai 2005 – 2011

Andre Kydd 2006 – 2014
Meredith Stone 2012
Michael Topper 2012

Research Interests

Molecular Determinants of Tumor Progression

Our laboratory group studies the molecular determinants of altered cellular differentiation in the evolution of selected human tumors. One focus involves delineating how differentiation features are lost from endocrine tumors during progression. Transcription factors that mediate peptide hormone gene expression are being defined and their role in mediating the endocrine cell phenotype is under study. Gene insertion studies are used to delineate the signal transduction steps that guide endocrine differentiation.

We have shown that, in human tumors, abnormal hypermethylation of CpG rich promoter regions is associated with loss of important tumor suppressor gene expression during tumor progression. We are continuing to define the genes involved with this alteration and to investigate the mechanisms underlying appearance of the methylation changes. Regulation of DNA methylation is being studied by characterization of the human DNA methyltransferase gene and the effects of its over and under expression in eukaryotic cells. To understand the role of abnormal methylation patterns, we are delineating, in experimental systems and selected human tumors, the relationships between abnormal DNA methylation sites, time of their appearance during tumor evolution and consequences for specific chromosome changes and gene expression events.

Publications

Research Profile

  • Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, Schuebel KE, Cui H, Feinberg AP, Lengauer C, Kinzler KW, Baylin SB, and Vogelstein B.DNMT1 and DNMT3b cooperate to silence genes in human cancer cells.Nature, 416: 552-556, 2002.
  • Suzuki H, Gabrielson E, Chen W, Anbazhagan R, van Engeland M,Weijenberg MP, Herman JG, and Baylin SB. A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in humancolorectal cancer. Nat Genet, 31: 141-149, 2002.
  • Chen WY, Zeng X, Carter MG, Morrell CN, Yen, RW, Esteller M,Watkins DN, Herman JG, Mankowski JL, and Baylin SB. Heterozygousdisruption of Hic1 predisposes mice to a gender-dependent spectrum ofmalignant tumors. Nat Genet, 33: 197-202, 2003.
  • Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy P, Baylin SB.Hedgehog signaling within airway epithelial progenitors and small cell lung cancer.Nature, 422: 313-317, 2003.