|Department Affiliations||Dept. of Radiation Oncology & Molecular Radiation Sciences, Urology Dept. of Oncology|
|Rank||Associate Professor, Clinical Director of Radiation Oncology and Molecular Radiation Sciences|
|SOM Address||406 Cancer Research Building II|
Broadly, my lab at Hopkins focuses our efforts on understanding pathways critical for the development, progression and maintenance of tumors of the prostate, lung and liver. One of our major specific interests are the transitions between epithelial and mesenchymal cellular states and the implications of these transitions for tumorigenesis, cancer treatment resistance and radiation-induced fibrosis. One of these transitions known as epithelial-mesenchymal transition (EMT) is a conserved developmental program that when inappropriately activated in post-natal life has been associated with organ fibrosis, tumorigenesis and metastasis (ref. 1). We study these areas primarily by using a novel suite of inducible transgenic oncogene mouse models (1,2,5) and non-invasive rodent imaging (3-5) as well as other more traditional biochemical, genetic, molecular and cell biological approaches. Our inducible mouse models afford us a unique ability to simulate molecularly targeted therapies for malignancies and other clinically germane phenotypes. One of these interesting and clinically relevant phenotypes we are interested in is known as “oncogene addiction” or the essential requirement for an initiating oncogene for tumor maintenance (1,2,5). Another focus of the laboratory is the study of novel targeted agents as tumor selective radiosensitizers to increase the therapeutic ratio of clinical radiotherapy (6,7). Embedded in the core DNA of the lab is an overarching goal to translate our basic findings into novel approaches to improve the prevention, diagnosis and treatment of human malignancies. We are committed and have proven we can translate discoveries from the bench into novel approaches that can be tested in the clinic.
- Phuoc T. Tran*+, Emelyn H. Shroff*, Timothy F. Burns* et. al. Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis. PLoS Genet 8 (2012) e1002650.* – these authors contributed equally; and + – corresponding authors. .
- Phuoc T. Tran*, Alice C. Fan*, Pavan K. Bendapudi*, et al. Combined Inactivation of MYC and K-ras Oncogenes Reverses Tumorigenesis in Lung Adenocarcinomas and Lymphomas. PLoS ONE 3 (2008) e2125. PMID: 18461184; PMCID: PMC2365560. * – these authors contributed equally. .
- Hu Zhou, Manuel Rodriguez, Fred van den Haak, Geoffrey Nelson, Rahil Jogani, Jiali Xu, Xinzhi Zhu, Yongjiang Xian, Phuoc T. Tran, Dean W. Felsher, Paul J. Keall, Edward E. Graves. Development of a MicroCT-Based Image-Guided Conformal Radiotherapy System for Small Animals. Int J Radiat Oncol Biol 78 (2010) 297-305. PMID: 20395069; PMCID: PMC2906632. .
- Carsten H. Nielsen, Richard H Kimura, Nadia Withofs, Phuoc T. Tran, Zheng Miao, Jennifer Cochran, Zhen Cheng, Dean Felsher, Andreas Kjær, Juergen K. Willmann, Sanjiv S. Gambhir. PET Imaging of Tumor Neovascularization in a Transgenic Mouse Model with a Novel 64Cu-DOTA-Knottin Peptide. Cancer Res 70 (2010) 9022-30. PMID: 21062977; PMCID: PMC3057960. .
- Phuoc T. Tran*, Pavan K. Bendapudi*, H. Jill Lin*, et. al. Survival and Death Signals Can Predict Tumor Response to Therapy After Oncogene Inactivation. Sci Transl Med 3 (2011) 103ra99**. PMID: 21974937. * – these authors contributed equally. ** – Highlighted by Comments in Sci Transl Med, Cancer Res, Nat Rev Clin Oncol and Cancer Discovery. .
- Jing Zeng, Alfred P. See, Khaled Aziz, Saravanan Thiyagarajan, Tarek Salih, Rajendra P. Gujula, Michael Armour, Jillian Phallen, Stephanie Terezakis, Lawrence Kleinberg, Kristen Redmond, Russell K. Hales, Roberto Salvatori, Alfredo Quinones-Hinojosa, Phuoc T. Tran+, Michael Lim+. Nelfinavir induces radiation sensitization in pituitary adenoma cells. Cancer Biol Ther 12 (2011) 657-63. PMID: 21811091. + – corresponding authors.
- Jing Zeng, Khaled Aziz, Sivarajan T. Chettiar, Blake Aftab, Michael Armour, Rajendra Gajula, Nishant Gandhi, Tarek Salih, Joseph M. Herman, John Wong, Charles M. Rudin, Phuoc T. Tran, Russell K. Hales. Hedgehog pathway inhibition radiosensitizes non-small cell lung cancers. Int J Radiat Oncol Biol Phy. (2012) In Press. PMID: 23182391.