Main navigation

Petros C. Karakousis, MD

Department Affiliations Department of Medicine, Johns Hopkins University School of Medicine Department of International Health, Johns Hopkins Bloomberg School of Public Health
Rank Associate Professor
Office Phone 410-502-8233
Lab Phone 410-502-8232
Fax 410-614-8173
SOM Address 110 CRB 2


Research Interests

The primary focus of the Karakousis Lab is to understand the molecular basis of persistence and reactivation in Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). Major research activities include studying the adaptation of M. tuberculosis to stress conditions believed to be important in the infected human host, as well as the phenomenon of phenotypic tolerance to antibiotics. In particular, the regulatory cascade involved in the mycobacterial stringent response is under active investigation. A systems biology-based approach is being used to identify host cytokine networks responsible for immunological control of M. tuberculosis growth, as well as M. tuberculosis regulatory and metabolic pathways required for bacillary growth restriction and reactivation. The laboratory is also actively investigating the repurposing of various clinically available agents with immune-modulatory properties as adjunctive host-directed therapy, in order to shorten the duration of TB treatment and improve lung function outcomes.