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Peter A. Calabresi, MD

Department Affiliations Clinical Neurosciences
Rank Professor
Office Phone 410-614-1522
Lab Phone
Fax
Email calabresi@jhmi.edu
SOM Address 509 Pathobiology
Website
www.calabresilab.com
Students

 

Inna Grishkan 2010 – 2015
Leslie Kirby 2010

Research Interests

The Calabresi lab studies the interface between the immune system and the CNS. Specifically, we are identifying the molecular mechanisms by which effector T cells inhibit endogenous remyelination mediated by oligodendrocyte precursor cells (OPC).

Publications

Calabresi Research Profile

  • Grishkan IV, Tosi DM, Bowman MD, Harary M, Calabresi PA, Gocke AR. Antigenic Stimulation of Kv1.3-Deficient Th Cells Gives Rise to a Population of Foxp3-Independent T Cells with Suppressive Properties. J Immunol. 2015. doi:10.4049/jimmunol.1403024.
  • Baxi EG, DeBruin J, Tosi DM, Grishkan IV, Smith MD, Kirby LA, Strasburger HJ, Fairchild AN, Calabresi PA, Gocke AR. Transfer of Myelin-Reactive Th17 Cells Impairs Endogenous Remyelination in the Central Nervous System of Cuprizone-Fed Mice. J Neurosci. 2015;35(22):8626-8639. doi:10.1523/JNEUROSCI.3817-14.2015.
  • Bhargava P, Gocke A, Calabresi PA. 1,25-Dihydroxyvitamin D3 impairs the differentiation of effector memory T cells in vitro in multiple sclerosis patients and healthy controls. J Neuroimmunol. 2015;279:20-24. doi:10.1016/j.jneuroim.2014.12.018.
  • Baxi EG, Schott JT, Fairchild AN, Kirby LA, Karani R, Uapinyoying P, Pardo-Villamizar C, Rothstein JR, Bergles DE, Calabresi PA. A selective thyroid hormone β receptor agonist enhances human and rodent oligodendrocyte differentiation. Glia. 2014;62(9):1513-1529. doi:10.1002/glia.22697.
  • Ntranos A, Hall O, Robinson DP, Grishkan IV, Schott JT, Tosi DM, Klein SL, Calabresi PA, Gocke AR. FTY720 impairs CD8 T-cell function independently of the sphingosine-1-phosphate pathway. J Neuroimmunol. 2014;270(1-2):13-21. doi:10.1016/j.jneuroim.2014.03.007.
  • Grishkan IV, Fairchild AN, Calabresi PA, Gocke AR. 1,25-Dihydroxyvitamin D3 selectively and reversibly impairs T helper-cell CNS localization. Proc Natl Acad Sci U S A. 2013;110(52):21101-21106. doi:10.1073/pnas.1306072110.
  • Grishkan IV, Ntranos A, Calabresi PA, Gocke AR. Helper T cells down-regulate CD4 expression upon chronic stimulation giving rise to double-negative T cells. Cell Immunol. 284(1-2):68-74. doi:10.1016/j.cellimm.2013.06.011.
  • Hu L, Wang T, Gocke AR, Nath A, Zhang H, Margolick JB, Whartenby KA, Calabresi PA. Blockade of Kv1.3 potassium channels inhibits differentiation and granzyme B secretion of human CD8+ T effector memory lymphocytes. PLoS One. 2013;8(1):e54267. doi:10.1371/journal.pone.0054267.
  • Gocke AR, Lebson LA, Grishkan IV, Hu L, Nguyen HM, Whartenby KA, Chandy KG, Calabresi PA. Kv1.3 deletion biases T cells toward an immunoregulatory phenotype and renders mice resistant to autoimmune encephalomyelitis. J Immunol. 2012;188(12):5877-5886. doi:10.4049/jimmunol.1103095.
  • Hu L, Gocke AR, Knapp E, Rosenzqeigh JM, Grishkan IV, Baxi EG, Zhang H, Margolick JB, Whartenby KA, Calabresi PA. Functional blockade of the voltage-gated potassium channel Kv1.3 mediates reversion of T effector to central memory lymphocytes through SMAD3/p21cip1 signaling. J Biol Chem. 2012;287(2):1261-1268. doi:10.1074/jbc.M111.296798.