|Department Affiliations||Departments of Neurology and Psychiatry|
|Rank||Professor and Vice Chair for Research in Neurology|
|SOM Address||517 Pathology|
Dr. Haughey directs a disease-oriented research program that address questions in basic neurobiology, and clinical neurology. The primary research interests of the laboratory are:
1) To better understand how the lipid components of neuronal, and glial membranes interact with proteins to regulate signal transduction associated with differentiation, motility, inflammatory signaling, survival, and neuronal excitability, and neural network connectivity.
2) To understand how extracellular vesicles (exosomes) released from brain resident cells regulate neuronal excitability, neural network activity, and peripheral immune responses to central nervous system damage and infections.
3) To develop small molecule therapeutics that regulate lipid metabolism as a neuroprotective and restorative strategy for neurodegenerative conditions.
4) To identify biomarkers markers for neurodegenerative diseases including HIV-Associated Neurocognitive Disorders, Multiple Sclerosis, and Alzheimer’s disease. In these studies, blood and cerebral spinal fluid samples obtained from ongoing clinical studies are analyzed for metabolic profiles through a variety of biochemical, mass spectrometry and bioinformatic techniques. These biomarkers can then be used in the diagnosis of disease, as prognostic indicators to predict disease trajectory, or as surrogate markers to track the effectiveness of disease modifying interventions.
- Dickens, A., Tovar-y–Romo, LB., Yoo, SW., Trout, AL., Bae, M., Kanmogne, M., Megra, B., Williams, , Witwer, K., Gacias, M., Tabatadze, N., Cole, R., Casaccia, P., Berman, JW., Anthony, DC., Haughey, NJ. Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions. Science Signaling. 2017. Apr 4;10(473).
- Yoo SW, Bae M, Tovar-Y-Romo LB, Haughey NJ. Hippocampal encoding of interoceptive context during fear conditioning. Translational psychiatry. 2017; 7(1).
- Hategan A, Bianchet MA, Steiner J, Karnaukhova E, Masliah E, Fields A, Lee MH, Dickens AM, Haughey N, Dimitriadis EK, Nath A. HIV Tat protein and amyloid-β peptide form multifibrillar structures that cause neurotoxicity. Nature Structural Molecular Biology. 2017 Apr;24(4):379-386.
- Saylor D, Dickens AM, Sacktor N, Haughey N, Slusher B, Pletnikov M, Mankowski JL, Brown A, Volsky DJ, McArthur JC. HIV-associated neurocognitive disorder – pathogenesis and prospects for treatment. Nat Rev Neurol. 2016;12(4):234-248.
- Dickens AM, Anthony DC, Deutsch R, Mielke MM, Claridge TD, Grant I, Franklin D, Rosario D, Marcotte T, Letendre S, McArthur JC, Haughey NJ. Cerebrospinal fluid metabolomics implicate bioenergetic adaptation as a neural mechanism regulating shifts in cognitive states of HIV-infected patients. 2015. 13;29(5):559-569.
- Mielke MM, Bandaru VV, Han D, An Y, Resnick SM, Ferrucci L, Haughey NJ. Demographic and clinical variables affecting mid- to late-life trajectories of plasma ceramide and dihydroceramide species. Aging Cell. 2015 Dec;14(6):1014-1023.
- Bae, M., Bandaru, VVR., Patel, N., Xu, H., Lee, M., Tominaga-Yamanaka, , Nath, A., Geiger, , Gorospe, M., Mattson, MP., Haughey, NJ. Activation of TRPML1 clears intraneuronal Aβ in preclinical models of HIV infection.J Neurosci. 2014. 34(34):11485-51103.