|SOM Address||204 Cancer Research Building II|
The Garza lab studies regenerative medicine and is focused on what controls tissue identity. In particular, how do stem cells maintain tissue identity despite constant cellular turn-over or during wound healing? We use the skin as our model system and ask this question in two contexts. Firstly, we study adult de novo organogenesis. It has recently been shown that certain wounds in mice can recapitulate embryogenesis and grow completely new hair follicles with associated stem cell compartments, vessels and nerves. Our lab is interested in understanding what controls this and how to promote adult organogenesis in the clinic. Secondly, we are interested in defining how malleable is skin identity given its heterogeneity on the human body. Can we reprogram skin identity such that for example new palmo-plantar type skin is generated at the stump site in an amputee? The results of this work have broad relevance since most of human disease is a result of fibrosis and scarring.
- Nelson AM, Reddy SK, Ratliff TS, Hossain MZ, Katseff AS, Zhu AS, Chang E, Resnik SR, Page C, Kim D, Whittam AJ, Miller LS, Garza LA. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration. Cell Stem Cell. 2015 Aug 6;17(2):139-51. PMID:26253200
- Nelson AM, Katseff AS, Ratliff TS, Garza LA. Interleukin 6 and STAT3 regulate p63 isoform expression in keratinocytes during regeneration. Exp Dermatol. 2015 Nov 14 PMID:26566817
- Amanda M. Nelson*, Adiya S. Katseff, Sydney R. Resnik, Tabetha S. Ratliff, Amadeus S. Zhu, and Luis A. Garza. Interleukin 6 null mice paradoxically display increased Stat3 activity and wound-induced hair neogenesis. J Invest Dermatol 2016 In Press.
- Garza LA, Yang CC, Zhao T, Blatt HB, Lee M, He H, et al. Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells. J Clin Invest. 2011;121(2):613-22. PMCID: PMC3026732.
- Garza LA, Liu Y, Yang Z, Alagesan B, Lawson JA, Norberg SM, et al. Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44. Sci Transl Med. 2012;4(126):126ra34. PMCID: PMC3319975.
- Christman AL, Selvin E, Margolis DJ, Lazarus GS, Garza LA. Hemoglobin A1c predicts healing rate in diabetic wounds. J Invest Dermatol. 2011;131(10):2121-7. PMCID: PMC3174328.