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Joseph L. Mankowski, DVM, PhD, Diplomate ACVP

Department Affiliations Director-Molecular and Comparative Pathobiology, Pathology, Neurology
Rank Professor
Office Phone 410-955-9770
Lab Phone 410-955-9770
Fax 410-955-9823
Email jmankows@jhmi.edu
SOM Address 811 Miller Research Building
Website
Students

Kelly Pate 2008 – 2013

Sarah Beck 2009 – 2014

Lisa Mangus 2011 – 2016

Research Interests

Pathogenesis of HIV-induced nervous system and cardiac disease processes

HIV is well known for its ability to induce loss of CD4+ T cells leading to immune suppression manifest as AIDS. HIV infection also causes debilitating disease in the brain, the peripheral nervous system, and in the heart secondary to infection of macrophages. Although virus-induced damage to these organs is common, the pathogenesis remains poorly defined. Using the SIV/macaque model of HIV, we use a multidisciplinary approach to dissect the mechanisms underlying these diseases, including the central role of macrophage activation. In addition, we are pursuing identification of surrogate biomarkers of HIV disease progression that can shed light on disease mechanisms and also be translated to the clinical setting. For example, we have recently characterized CSF markers (IL-6 and 14-3-3 proteins) and hematologic markers (platelet decline) that precede and predict SIV and HIV CNS disease. Close ties to clinical groups in JHU Neurology and Cardiology facilitate these efforts.

Our group is also interested in defining how glial and endothelial cells in the brain respond to systemic immune stimuli including the mechanisms underlying transduction of pro-inflammatory peripheral immune signals to the CNS across the blood-brain barrier. To investigate these fundamental issues in communication biology, we use the SIV-macaque model of HIV CNS disease.

Publications

Research Profile