|Department Affiliations||Neurosurgery, Oncology & Genetic Medicine|
|SOM Address||Room 257 Cancer Research Building II|
The goal of the Brain Cancer Biology and Therapy Laboratory (Riggins Lab) is to locate the genetic and genomic changes that lead to brain cancer. The technologies we employ search large portions, or entire cancer genome, for cancer-causing DNA changes. The molecular changes are evaluated for how they contribute to cancer development. The alterations discovered are mutations, amplifications and abnormally expressed genes. Our goal is to find the critical new molecular functions that the tumor gains and determine quickly if counteracting the mutation can slow or kill cancer cells, including cancer stem cells. We are using this information to develop better brain cancer therapy. This is done in part by screening drug and chemical libraries to identify small molecules that kill mutation containing cancer cells. Animal models are used to test possible new anti-cancer compounds.
- Trembath DG, Lal A, Kroll DJ, Oberlies NH, Riggins GJ. A novel small molecule that selectively inhibits glioblastoma cells expressing EGFRvIII. Mol Can. 2007 Apr 16;6:30
- Cerutti J., Oler G., Michaluart P., Delcelo R., Beaty R., Shoemaker J., and Riggins GJ. Molecular Profiling of Matched Samples Identifies Biomarkers of Papillary Thyroid Carcinoma Lymph Node Metastasis. Cancer Research 2007: 67 (16).
- Beaty RM, Edwards JB, Boon K, Siu IM, Conway JE, and Riggins GJ. PLXDC1 (TEM7) is identified in a genome-wide expression screen of glioblastoma endothelium. J Neurooncol. 2006 Sept 20.
- Gallia GL, Rand V, Siu IM, Eberhart CG, James CD, Marie SK, Oba-Shinjo SM, Carlotti CG, Caballero OL, Simpson AJ, Brock MV, Massion PP, Carson BS, Sr., and Riggins GJ. PIK3CA gene mutations in pediatric and adult glioblastoma multiforme. Mol Cancer Res. 2006; 4:709-714.
- Rand V, Huang J, Stockwell T, Ferriera S, Buzko O, Levy S, Busam D, Li K, Edwards JB, Eberhart C, Murphy KM, Tsiamouri A, Beeson K, Simpson AJ, Venter JC, Riggins GJ, and Strausberg RL. Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas. Proc Natl Acad Sci U S A. 2005; 102:14344-14349