|Department Affiliations||Medicine, Institute for Cell Engineering|
|SOM Address||954 Ross|
Our lab focuses on understanding the cellular and molecular mechanisms governing heart generation and regeneration. Heart malformation is the most frequent form of human birth defects, and cardiovascular disease is the leading cause of death worldwide. We seek to understand the fundamental biology and regenerative potential of multi-potent cardiac progenitor cells – building blocks used to form the heart during fetal development — by deciphering the molecular and cellular mechanisms that control their induction, maintenance, and differentiation. We are also interested in elucidating the maturation event of heart muscle cells, an essential process to generate adult cardiomyocytes, which occurs after terminal differentiation of the progenitor cells. We believe this knowledge will contribute to our understanding of congenital and adult heart disease and be instrumental for stem cell-based heart regeneration.
- Oh Y, Cho GS, Li Z, Hong I, Zhu R, Kim MJ, Kim YJ, Tampakakis E, Tung L, Huganir R, Dong X, Kwon C*, Lee G* (2016) Functional Coupling with Cardiac Muscle Promotes Maturation of hPSC-derived Sympathetic Neurons. Cell Stem Cell. 19(1):95-106 *Co-senior
- Uosaki H, Cahan P, Lee DI, Wang S, Miyamoto M, Fernandez L, Kass D, Kwon C. (2015) Transcriptional Landscape of Cardiomyocyte Maturation. Cell Rep. 13(8):1705-16
- Kwon C, Tomaselli GF. (2015) Coins of the Realm in Atroventricular Junction Development. Circ Res. 30;116(3):386-8
- Shenje L, Andersen P, Uosaki H, Fernandez L, Cho GS, Rainer P, Zhong W, Harvey RP, Kass DA, Kwon C (2014) Precardiac Deletion of Numb and Numblike Reveals Renewal of Cardiac Progenitors. 3:e02164
- Shenje L, Andersen P, Halushka M, Lui C, Fernandez L, Collin G, Amat-Alarcon N, Meschino M, Cutz E, Chang K, Yonescu R, Batista D, Chen Y, Chelko S, Crosson J, Scheel J, Vricella L, Craig B, Marosy B, Mohr D, Hetrick K, Romm J, Scott A, Valle D, Naggert J, Kwon C, Doheny KF, Judge DP. (2014) Mutations in Alström Protein Impair Terminal Differentiation of Cardiomyocytes. Nat Commun. 4;5:3416