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Alex L. Kolodkin, PhD

Department Affiliations Neuroscience
Rank Professor
Office Phone 410-614-9499
Lab Phone 410-614-9497
Fax 410-614-8423
Email kolodkin@jhmi.edu
SOM Address 1001 PCTB
Website

Kolodkin Website

Students

Joelle Dorskind 2015

Research Interests

Research in my laboratory is focused on understanding how neuronal connectivity is established during development. Our work investigates the function of extrinsic guidance cues and their receptors on axonal guidance, dendritic morphology, and synapse formation and function. For several years we have investigated how neural circuits are formed and maintained through the action of guidance cues, including but not limited to semaphorin proteins, their classical plexin and neuropilin receptors, and also novel receptors. We also employ a cross phylogenetic approach, using both invertebrate and vertebrate model systems, to understand how guidance cues regulate neuronal pathfinding, morphology, and synaptogenesis. Though broad in scope, our interrogation of the roles played by semaphorins, and also other guidance cues, provides insight into the regulation of neural circuit assembly and function. As a result of past and ongoing projects in my laboratory, I and my colleagues have extensive experience in mouse and fly genetic manipulations and a wide range of neuroanatomical analyses. Our current work includes a relatively new interest in understanding the origins of laminar organization in the central nervous system. This direction has resulted in our identification of guidance cues and receptors that regulate both specific and general aspects of neurite stratification in the mouse retina, in addition to the targeting of retinal ganglion cell axons to retinorecipient midbrain targets.

Publications

Research Profile

  • Riccomagno, M, Hurtado, A., Wang, H.-B., Macopson, J.G.J., Griner, E.M., Betz, A., Brose, N. Kazanietz, M.G., and Kolodkin, A.L. (2012). The RacGAP-Chimaerin selectively mediates stereotyped hippocampal axon pruning. Cell 149, 1594–1606 [PMCID: PMC3395473].
  • Sun, L.O., Jiang, Z., Rivlin-Etzion, Michal, Hand, R., Brady, C., Matsuoka, R.L., Yau, K.-w., Feller, M.B., and Kolodkin, A.L. (2013). On versus Off direction selective retinal circuits require different molecular mechanisms for functional assembly (Article). Science, 342,1241947: DOI:10.1126/science.1241974 [PMCID In Progress; NIHMSID#: 544230].