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Alan Meeker, PhD

Department Affiliations Departments of Pathology, Oncology and Urology
Rank Associate Professor
Office Phone 410-502-3398
Lab Phone
Fax 410-502-5158
SOM Address Room B300 Bond St. Research Annex

Walter Barry 2011

Research Interests

The overarching research focus of the Meeker lab is on cancer. The primary emphasis is on abnormal telomere biology as it relates to cancer initiation and tumor progression. To this end, we utilize a range of tissue-based, cell-based and molecular approaches. A secondary focus of the lab is on cancer biomarker discovery and validation, including biomarkers for cancer diagnosis, prognosis and prediction of response to therapy. The ultimate goal of our research endeavors is to foster the development of novel translational applications useful in the spheres of cancer prevention, diagnosis, prognostication and treatment


Research Profile

• Heaphy CM, de Wilde RF, Jiao Y, Klein AP, Edil BH, Shi C, Bettegowda C, Rodriguez FJ, Eberhart CG, Hebbar S, Offerhaus GJ, McLendon R, Rasheed BA, He Y, Yan H, Bigner DD, Oba-Shinjo SM, Marie SK, Riggins GJ, Kinzler KW, Vogelstein B, Hruban RH, Maitra A, Papadopoulos N, Meeker A.K. Altered Telomeres in Tumors with ATRX and DAXX Mutations. Science. 2011; 22:333; 425. PMID: 21719641 PMCID: PMC3174141.

• Heaphy CM, Subhawong AP, Hong SM, Goggins MG, Montgomery EA, Gabrielson E, Netto GJ, Epstein JI, Lotan TL, Westra WH, Shih IeM, Iacobuzio-Donahue CA, Maitra A, Li QK, Eberhart CG, Taube JM, Rakheja D, Kurman RJ, Wu TC, Roden RB, Argani P, De Marzo AM, Terracciano L, Torbenson M, Meeker A.K. Prevalence of the Alternative Lengthening of Telomeres (ALT) Telomere Maintenance Mechanism in Human Cancer Subtypes. Am Jol Pathology. 2011; 179(4):1608-1615. PMID: 21888887.

• Christopher M. Heaphy, Ghil Suk Yun, Sarah B. Peskoe, Corinne E. Joshu, Thomas K. Lee, Edward Giovannucci, Lorelei A. Mucci, Stacey A. Kenfield, Meir J. Stampfer, Jessica L. Hicks, Angelo M. De Marzo, Elizabeth A. Platz, Meeker A.K.. Prostate Cancer Cell Telomere Length Variation and Stromal Cell Telomere Length as Prognostic Markers for Metastasis and Death. Cancer Discovery. 2013; Oct; 2(10):1130-41. PMID:23779129

• Michael C. Haffner, Timothy Mosbruger, David M. Esopi, Helen Fedor, Christopher M. Heaphy, Nkosi Adejola, Meltem Gürel, Jessica Hicks, Meeker A.K., Marc K. Halushka, William B. Isaacs, Angelo DeMarzo, William G. Nelson, Srinivasan Yegnasubramanian. Tracking the Clonal Origin of Lethal Prostate Cancer. 2013 Nov 1;123(11):4918-22. PMID:24135135.

• Foteini Mourkioti, Jackie Kustan, Peggy Kraft, Ming-Ming Zhao, Maria Alimova, Ronald DePinho, Daniel Bernstein, Meeker A.K., Helen M. Blau. Combined Telomere Dysfunction and Dystrophin Deficiency lead to Chronic Oxidative Stress and Cardiac Failure in Duchenne Muscular Dystrophy. Nature Cell Biology. 2013 Aug;15(8):895-904. PMID:2383172