|Department Affiliations||Neurology, Neuroscience|
|SOM Address||248 Rangos|
My laboratory is interested in basic biology of peripheral axons and Schwann cells and disorders affecting the peripheral nervous system. We use in vitro and in vivo models of peripheral neuropathies (HIV-associated sensory neuropathies, chemotherapy-induced toxic neuropathies and diabetic neuropathy) to study the mechanism of axonal damage and identify therapeutic targets for drug development. In addition, we study mechanisms of axonal degeneration and regeneration in traumatic injury and develop nanofiber based nerve graft conduits. We utilize engineered stem cells as therapeutic gene delivery tools to promote axonal regeneration in chronically denervated nerves as seen traumatic injuries and many degenerating disorders of the peripheral nervous system such as amyotrophic lateral sclerosis and inherited neuropathies.
- Zhu J, Chen W, Mi R, Zhou C, Reed N, et al. Ethoxyquin prevents chemotherapy-induced neurotoxicity via Hsp90 modulation. Ann Neurol. 2013 Dec;74(6):893-904. PubMed PMID: 23955554.
- Zhu J, Carozzi VA, Reed N, Mi R, Marmiroli P, Cavaletti G, Hoke A. Ethoxyquin provides neuroprotection against cisplatin-induced neurotoxicity. Sci Rep. 2016 Jun 28;6:28861. doi: 10.1038/srep28861. PMID: 27350330 Free PMC Article
- Lehmann HC, Chen W, Borzan J, Mankowski JL, Höke A. Mitochondrial dysfunction in distal axons contributes to human immunodeficiency virus sensory neuropathy. Ann Neurol. 2011 Jan;69(1):100-10. PubMed PMID: 21280080; PubMed Central PMCID: PMC3051401.
- Wright MC, Mi R, Connor E, Reed N, Vyas A, et al. Novel roles for osteopontin and clusterin in peripheral motor and sensory axon regeneration. J Neurosci. 2014 Jan 29;34(5):1689-700. PubMed PMID: 24478351; PubMed Central PMCID: PMC3905142.
- Scheib JL, Höke A. An attenuated immune response by Schwann cells and macrophages inhibits nerve regeneration in aged rats. Neurobiol Aging. 2016 Sep;45:1-9. doi: 10.1016/j.neurobiolaging.2016.05.004. Epub 2016 May 11. PMID: 27459920